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Figure 5.
Fig. 5. The CDR side chains of YADS1 (A) and YADS2 (B) that
contact hVEGF. The structural epitope for binding to the Fab
(see Fig. 3) was mapped onto the molecular surface of hVEGF, and
residues that made contacts with tyrosines or other residue
types are colored orange or blue, respectively. The side chains
at CDR positions that were randomized in the libraries are
shown. Side chains that do not make contact with hVEGF are
colored white. Tyrosine side chains that make contacts with
hVEGF are colored red, whereas all other contacting side chains
are colored blue. The hVEGF molecules are shown in the same
orientation in both panels.
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