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Figure 5.
Figure 5. Divergence and disappearance of the structural
tetrad in representative Ski8p blades. (A) Blade 1 contains a
nearly conventional tetrad involving hydrogen bonding between
the side chains of Trp 41, Ser 31, and His 15. The aspartate
completes the tetrad in the canonical structure. (B) Blade 3 has
Trp 153 and Asp 145 at the expected positions, but other
residues are divergent. The core of this blade is stabilized via
a mixture of hydrogen bonding and hydrophobic interactions. (C)
Blade 7 contains residues that are homologous in sequence to a
conventional tetrad. The positions are structurally divergent,
however.
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