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Figure 5.
(a) A model representing the microenvironment from pH 4.5 to
7.3, where FAD is in the neutral oxidized form and His447 is in
the imidazole form protonated at NE2. (b) A model representing
the microenvironment at pH 9.0, where the negative charge of the
imidazolate form of His447 is stabilized by interaction with
Asn321 and Asn323.
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