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Figure 5.
Figure 5 Schematic views of the VavS -GrbS A interface. (A) The
molecular surface of VavS is shown as a transparent worm with
the VavS -GrbSA interface close to the viewer. The VavS residues
at the interface are drawn as green rods. For clarity, some
residues that interact minimally with GrbS A are omitted
(His634, Cys652, Val655 and His 656). The polypeptide backbone
of the N-terminal tail derived from the expression vector is
traced as a dotted line in white. (B) The side chains (rods) and
polypeptide backbone (magenta tubes) of the GrbS residues at the
interface are superposed on VavS. (C) The molecular surfaces of
the Abl (left) (Musacchio et al., 1994) and Hck (right) (Sicheri
et al., 1997) SH3 domains are shown in the same orientation as
that of VavS in (A) and (B). Only the regions corresponding to
residues 595 -659 of VavS are shown.
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