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Figure 4.
Figure 4. F[o] - F[c] maps contoured at 2.0 s for the leech
IT-sialidase complexes with (a) inactive substrate analogue
2-propenyl-Neu5Ac (the terminal carbon in the 2-propenyl is not
shown). There is no density for the two terminal carbon groups
in 2-propenyl. In addition, 6-glycerol appears disordered with a
bulk density. (b) Product 2,7-anhydro-Neu5Ac; (c) also product
2,7-anhydro-Neu5Ac, soaked with substrate 3'-sialyllactose.
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