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Figure 4.
Fig. 4. Comparison between p14·SF3b155 peptide
surface and structures of U1A and U2AF65 RRM3. (A)(Left) NMR
structure of free U1A with C-terminal helix (in yellow)
positioned across RNA-binding surface (19). (Middle) X-ray
structure of free U1A showing C-terminal helix rotated to unmask
the RNA binding surface (20). (Right) Structure of
p14·SF3b155 complex showing C-terminal helices of p14 and
Sf3b155 peptide (in yellow). RNP1 and RNP2 are colored red and
blue, respectively. (B) Representation of surface charges of
p14·SF3b155 and U2AF homology motif (RRM3) of U2AF^65.
The color scheme is as follows: blue, basic; red, acidic; white,
neutral.
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