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Figure 4.
Figure 4. Multiple Binding Modes Found in the FERM Domain
of ERM Proteins
(A) The radixin FERM domain (gray)
complexed with IP3 (Hamada et al., 2000), which is shown as a
ball-and-stick model. Italic labels indicate subdomains A, B,
and C.
(B) The radixin FERM domain complexed with the
ICAM-2 cytoplasmic peptide (magenta) (Hamada et al., 2003).
(C) The radixin FERM domain complexed with the NHERF-1 peptide
(blue; this work).
(D) The moesin FERM domain complexed the
C-tail domain (dark brown) (Pearson et al., 2000).
(E) The
C-tail domain (brown) is superimposed with the NHERF-1 peptide
(blue) bound to the radixin FERM domain (gray).
(F)
Comparison of the C-terminal helix of the NHERF-1 peptide (light
blue) bound to the radixin FERM domain and helix D of the moesin
C-tail domain (brown).
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