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Figure 4.
FIG. 4. Thrombin and its interactions with inhibitors. a,
superposition, in stereo, of thrombin or S195A thrombin
structures of complexes with PPACK (gold) (Protein Data Bank
code 1HAI [PDB]
), with BPTI (green) (Protein Data Bank code 1BTH [PDB]
), and with heparin cofactor II (red) (Protein Data Bank code
1JMO [PDB]
), showing the identical conformations of all regions except the
surface loops flanking the active site, particularly the 60 loop
and 150 loop. b, stereo representation of the P5-P5' residues of
 [1]PI Pittsburgh (cyan)
from the noncovalent complex with S195A trypsin docked into the
thrombin structure found in the noncovalent complex of S195A
thrombin with heparin cofactor II (HCII in magenta).
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