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Figure 4.
FIG. 4. Comparison of the relative orientations of POU[S]
and Sox2 in the ternary Oct1·Sox2·Hoxb1-DNA (left)
and Oct1·Sox2·FGF4-DNA (right) complexes. The
separation between the POU[S] and Sox2 binding sites is
increased by three base pairs (shown in magenta) in the FGF-4
element relative to the Hoxb1 element. This translates to a
difference of 108° in the relative orientations POU[S] and
Sox2 in the two ternary complexes. Sox2 is displayed in green,
Oct1 in red, and the DNA backbone in blue; the backbone of
residues at the POU[S]/Sox2 interface is highlighted in yellow.
The coordinates of the Oct1·Sox2·FGF4-DNA complex
are taken from Ref. 45 (PDB accession code 1GT0 [PDB]
).
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