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Figure 4.
Figure 4. Surface electrostatic potential of part of the
binding site of 2-Me-Tet-AMPA in complex with S1S2J. Positive
potential is coloured in blue and negative potential in red, as
indicated by the coloured bar to the left. The labelled residues
form a well-defined partly hydrophobic and partly polar
cavity within the binding site of S1S2J. These residues are
within 3.9 Å from the 2-methyltetrazole ring, except from
residues Thr686 and Leu704, which are at a distance of 4.2
Å and 4.7 Å, respectively. The ligand 2-Me-Tet-AMPA
is shown in ball-and-stick representation, coloured as follows:
carbon is white, oxygen is red, and nitrogen is blue. The Figure
was prepared with the program Sybyl (Tripos Assoc. Inc.).
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