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Figure 4.
Figure 4. Structure of the new fragment reaction products bound
to the ribosome. a, A space-filling representation of the 50S
particle (RNA in white and protein in yellow) in complex with
products, with the three tRNAs as they were observed^25 binding
to the Thermus thermophilus 70S ribosome superimposed for
reference. The subunit has been split through the tunnel, and
the front half was removed to reveal the tunnel and the peptidyl
transferase site (boxed). The orientation is the crown view,
with the L1 protein to the left and the L7−L12 stalk to the
right. b, A close-up view of the active site shows that the
peptidyl-product (CC-Pmn-pcb) (green) binds the A-loop (yellow),
whereas the deacylated product (CCA) (violet) base pairs to the
P-loop (blue). The N3 of A2486 (A2451) (light blue) is in
proximity to the 3' OH of the deacylated product, and the base
of U2620 (U2585) (red) has moved near to the newly formed
peptidyl ester link and the 3' OH of dimethyl A76.
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