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Figure 4.
FIG. 4. Selected close-up views of native and mutant
DHODAs. a, alignment of the subunit A of native DHODA orotate
complex (violet) and the K213E(Oro) structure (green). FMN and
orotate are shown as yellow and orange stick models,
respectively. The figure visualizes the difference between the
open active site loop and the closed active site loop. A
different view of the active site highlighting the interactions
between protein and orotate (in orange) is shown for the native
orotate complex (b) and N67A(Oro) (c), with the FMN group
colored in magenta. Hydrogen bonds are shown as black dotted
lines and selected water molecules are represented as cyan
spheres.
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