Figure 4.
Figure 4 Domain III shares similar characteristics with a C[2]
domain. A typical C[2] domain exists as an anti-parallel -sandwich
with several acidic residues at one end that form a binding
cradle for Ca^2+. The first C[2] domain from synaptotagmin
(cyan, PDB accession code 1RSY) (Sutton et al., 1995) and D-III
(green) have approximately the same overall dimensions, though
slightly differing topologies. Numerous acidic residues (red)
result in a highly negative potential, which is partially
stabilized by adjacent basic residues (blue).
-sandwich
with several acidic residues at one end that form a binding
cradle for Ca^2+. The first C[2] domain from synaptotagmin
(cyan, PDB accession code 1RSY) (Sutton et al., 1995) and D-III
(green) have approximately the same overall dimensions, though
slightly differing topologies. Numerous acidic residues (red)
result in a highly negative potential, which is partially
stabilized by adjacent basic residues (blue).