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Figure 4.
Fig. 4. The crystal structures of the V32D/F57H mutant near
the portal region. The stereodiagram contains a ball and stick
representation of the crystal structures of the V32D/F57H mutant
near the expected portal region of ALBP. Notice His57 is
hydrogen bonded to Ser55 in the pH 4.5 form, but makes a bond
with Asp32 in the pH 6.4 form. The methyl end of HDS is shown as
well, illustrating the residues close proximity to the ligand.
HDS binding was modeled^ after the V32D/F57H mutant coordinates
were aligned with the crystal structure of ALBP containing bound
HDS.
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