|
Figure 3.
Model for the CD47-SIRPα complex formed between interacting
cells. The entire extracellular CD47-SIRPα complex, modeled by
superposing the structure of SIRPα domains 1–3 onto the
structure of CD47 in complex with SIRPα domain 1 (5), is shown
as a blue (SIRPα) and yellow (CD47) molecular surface.
Schematic representations of the five transmembrane helices of
CD47 (yellow cylinders) and single transmembrane helix of SIRPα
(blue cylinder) are shown. The regions between transmembrane
helices and resolved structures for CD47 and SIRPα are
illustrated as dotted lines. The location of CD47 residue
Cys^15, which forms a disulfide bond with Cys^245 (proposed to
reside in the extracellular loop between transmembrane helices 4
and 5), is highlighted in red.
|
