Figure 3 - full size

Figure 3.
Fig. 3. CTE binding to the bottom face of the -propeller. (A) The surface of the Nup214 -propeller is colored according to the electrostatic potential from –10 k[B]T (red) to + 10 k[B]T (blue). The CTE is shown in blue coil representation with the side chains in ball-and-stick representation. The black box indicates the region magnified in D. (B) Hydrophobic interactions of CTE residues Val-410, Leu-413, and Leu-414 (yellow). (C) Interactions of Leu-420 and Leu-422 (yellow) with residues of the -propeller. Hydrophobic pocket-forming residues are shown in gray. The surface of the -propeller is colored as in A. (D) Schematic representation of the contacts between the -propeller and the CTE. Hydrogen and ionic bonds are indicated by orange dashed lines and van der Waals contacts with gray grooves.