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Figure 3.
Structure of full-length UvsW.A, actual crystal structure
showing the molecule in the open conformation. B, structure in
the modeled closed conformation in which domains 2A and 2B have
been rotated according to the structure of NS3-ssDNA. Each
domain is labeled. Key conserved residues within the helicase
motifs and the two flexible loops are shown, and these are
colored blue and pink to reflect interactions with DNA and
nucleotide, respectively. Note that in the closed conformation,
the helicase motifs congregate at the domain interface and the
two flexible loops are at the top of the molecule. The figures
were produced using MOLSCRIPT (57) and rendered with RASTER3D
(58).
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