|
Figure 3.
FIGURE 3. Structural basis of inhibition. The SU11652
inhibitor interacts with the ATP binding cleft through a network
of hydrogen-bonding interactions with main-chain atoms from the
kinase hinge region and van der Waals interactions with residues
from the N and C lobe together with Leu-162 from the  T helix.
The structure of the inhibitor is shown in the inset. The
(diethylamino)ethyl moiety (highlighted) is disordered in the
crystal structure.
|
