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Figure 3.
FIGURE 3. Role of the JM domain in stabilizing the inactive
form of cFMS. cFMS is shown in a white surface representation,
the activation loop (red) and the JM domain (yellow) were
excluded from the surface calculation and are represented as red
and yellow schemes, respectively. Trp^550 is also represented as
a surface. The activation loop of activated cKIT (PDB-ID 1PKG),
superimposed onto cFMS, is shown in green. In its autoinhibited
state, the JM domain of cFMS inserts itself into the active site
and prevents the activation loop from switching into an active
conformation.
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