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Figure 3.
Proposed mechanisms of the Gfh1 action. A and B, the
flexibility and the number of the acidic residues at the CC tip
of Gfh1 allow for the alternative binding (MG1 or MG2) of the
Mg^2+ ions. C, two hypothetical pathways (competitive and
noncompetitive) by which the Gfh1 protein may inhibit nucleotide
addition. cMg1 and cMg2 are the two catalytic metals, whereas
iMg is a putative inhibitory Mg^2+ ion.
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