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Figure 3.
FIGURE 3. C-terminal extended loop packed to the HRDC core.
A,a stick model represents carbon atoms of the nine C-terminal
residues (1227–1235, labeled with one-letter codes) shown in
cyan, whereas the other part of the domain including N-terminal
extended helix  1 is in green. The
composite-omit density map (25) for the C-terminal residues is
shown at the contour level of 1  . The orientation is
similar to that in Fig. 2A (top view). B, schematic
representation depicting the interactions between the C-terminal
extended loop (cyan) and HRDC core, including helix 1(green). Hydrogen
bonds are shown as dashed lines with distances (Å) shown.
Two hydrophobic pockets on the HRDC core (pocket-1 formed by
side chains from Thr^1152, Phe^1222, Cys^1223, and Asn^1226, and
pocket-2 formed by Met^1190, Pro^1192, Asn^1197, Ile^1201, and
Arg^1200) that are important for the binding of C-terminal
residues are indicated.
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