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Figure 3.
Figure 3
(a) The 2F[o] - F[c] [168][sigma] [A]-weighted electron-density map (shown in cyan) for
the inhibitor 4,7-dioxosebacic acid at 2.60 Å resolution. The covalent bonds between the
inhibitor and lysines 200 and 253 are also shown. (b) The hydrogen bonds made by the
carboxyl groups of the inhibitor with surrounding residues (donor-acceptor distances are
shown in Å). The atoms labelled C4 and C7 are attached to the invariant lysine residues by
Schiff bases. In both (a) and (b) the map is contoured at 1.25 r.m.s. and the A-site of
the enzyme is on the left-hand side, with the P-site on the right.
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