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Figure 3.
Fig. 3. Effect of loop 1 redesign on WW domain stability.
(a) Normalized equilibrium unfolding transitions for Pin WW
(variant 1) and variants 2–6 with either a confirmed (2) or
predicted (3–6) (3:5) type-I bulge turn. (b) Normalized
equilibrium unfolding transitions for variants 1 and 7–9 with
either a confirmed (7) or predicted (8, 9) (2:2) type-I'  -hairpin
turn. (c) Normalized equilibrium unfolding transitions for FBP
(WW variant 10) with a confirmed (3:5) type-I G1 bulge turn and
variant 11 with a predicted (4:6) loop.
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