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Figure 3.
Figure 3: Accurate translesion replication of 8oxoG by BF in
crystals. a, Schematic of BF active site. During replication,
the template base (n, red) moves from the pre-insertion site to
the post-insertion site to the DNA duplex binding region. b-d,
Structures of accurate 8oxoG replication (blue) are superimposed
with structures of unmodified guanine replication (grey). The
8oxoG template base (red) is shown at the pre-insertion site (b)
before nucleotide incorporation, the post-insertion site (c)
after dCTP incorporation, and the DNA duplex binding region (d)
after extension of C  8oxoG.
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