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Figure 3.
Fig. 3. The structural epitope for binding to YADS1 (A) or
YADS2 (B) mapped on the molecular surface of hVEGF. The
structural epitope consists of hVEGF residues that make contact
with one or more residues of the Fab, with "contact" defined as
a distance <4.1 Å. Residues that contact the heavy or
light chain are colored green or yellow, respectively. The
dashed line outlines the structural epitope for binding to
Flt-1[D2], as determined from a previously described x-ray
structure (PDB code 1FLT [PDB]
) (34).
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