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Figure 3.
Fig. 3. Schematic illustration of the predicted effect of
PA clamps on nucleosome dissociation. In the absence of ligand
binding, nucleosome dissociation initiates with unraveling of
the DNA ends, followed by dissociation of the (H2A-H2B) dimers,
and finally by the dissociation of the (H3-H4)[2] tetramer.
Binding clamp to the nucleosomes leads to the formation of a
closed  80-bp DNA supercoil that
prevents further disassembly of the nucleosomes.
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