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Figure 3.
Figure 3: The actin -myosin interface. a, Myosin V as viewed
from the actin side of the interface reveals the positioning of
putative actin-binding elements. b, The same view of myosin V is
overlaid on the lower 50-kDa subdomains of Dictyostelium myosin
II structures. Note the conformational change in the strut and
the obvious rotation of the upper 50-kDa subdomain towards the
actin filament (represented by an arrow) in the myosin V
structure. c, The myosin V and transition state actin-binding
elements are docked on an actin filament, maintaining the
identical positioning of the lower 50-kDa subdomain in both
cases. In myosin V, the HCM loop has been repositioned in such a
way that it can directly contribute to actin binding.
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