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Figure 3.
Figure 3. Details of the interactions between the +1 and +2
pTyr positions and the Src SH2 domain. (A) Stereo-ribbon diagram
of the Src SH2 domain bound to the pYEpYI complex.[56.]
Side-chains in the SH2 domain that interact with the +1 Glu and
+2 pTyr are shown in ball-and stick representation with carbon
atoms in dark gray, nitrogen in blue, oxygen in red, and
phosphorus in magenta. The corresponding residues are labeled.
The peptide is represented as in Figure 1(C) with thicker bonds.
Only the +2 pTyr and +1 Glu are labeled. Water molecules are
shown as balls, red for those observed in both the bound and
unbound forms of the SH2 domain, black for those only observed
in the bound form. Water molecules are labeled from 1 to 13 in
Figure 3, Figure 4 and Figure 5. (B) Schematic diagram of
interactions represented in A between the +1 Glu and +2 pTyr
residues and the Src SH2 domain. Residues in the protein are
shown in blue while the peptide is in black. Water molecules are
labeled as in (A). Contacts are indicated by dotted lines
linking the contacting atoms and the distances between
contacting atoms are indicated. Red dotted lines indicate
contact with water molecules. Black dotted lines indicate direct
contacts between peptide and protein.
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