|
Figure 3.
Figure 3. The active site. a, A CPK model showing the
distribution of conserved residues. Identical and similar
residues among the four proteins shown in Fig. 1a are shown in
blue and magenta, respectively. The area enclosed in the dashed
lines has the highest concentration of conserved residues. The
model is viewed in the same orientation as in Fig. 2a. b, A
surface representation of the structure. Red, blue and white
indicate negatively charged, positively charged and neutral
surface potentials. The structure is shown in the same
orientation as in (a), and the same area is enclosed by a yellow
dashed line. A blue arrow points to the cleft where Arg 406
resides. c, Stereo view of the conserved area shown in (a,b).
The side chains of several conserved residues are shown as stick
models (carbon, orange; nitrogen, blue; oxygen, red; sulfur,
magenta) superimposed with a ribbon drawing of the structure as
in Fig. 2a. Key residues are labeled.
|
