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Figure 3.
Fig. 3. The ligand-binding site of GluR2-S1S2J. A:
Interactions between GluR2-S1S2J and (S)-Des-Me-AMPA. Dashed
lines indicate potential hydrogen bonds/ionic interactions (up
to 3.3 Å). Water molecules are displayed as red spheres.
Nitrogen atoms are shown in blue, oxygen atoms in red, and
sulfur atoms in dark green. B: Superimposition of the
(S)-Des-Me-AMPA (cyan), (S)-AMPA (green), (S)-2-Me-Tet-AMPA
(magenta) and (S)-glutamate (yellow) complexes (shown in
stereo). For all structures MolA is used as a representative.
The conformation of Met708 in the glutamate complex is unique
for MolA, as the other two molecules have extended Met708 chains.
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