Figure 3.
Fig. 3. CPK model of the region around the cavity. The three
consecutive proline residues in Ad12 knob partially shape the
cavity, which is colored magenta. The AB loop, whose carbon
atoms are colored yellow, lines one side of the cavity. The
carbon atoms from the remainder of the monomer are colored red,
those of the second knob monomer, green, and those of CAR D1,
cyan. All oxygen and nitrogen atoms are colored light red and
blue, respectively. The cavity is lined with atoms from residues
,
(backbone),
(side),
V448 (side), (backbone),
V450, L455 (side), Q535 (side), P573 (side), and S575 (side)
from one Ad12 knob; S514 (backbone), A515 (backbone), (side),
N520 (side), A524 (main), E523, K525, and S526 (side) from the
other Ad12 knob; and L39 (side), K47 (backbone), V48 (backbone),
D49, Q50, V51, and K102 (side) from CAR. The underlined residues
are conserved or similar in all CAR-binding Ad serotypes.
,
(backbone),
(side),
V448 (side), 
(backbone),
V450, L455 (side), Q535 (side), P573 (side), and S575 (side)
from one Ad12 knob; S514 (backbone), A515 (backbone), 
(side),
N520 (side), A524 (main), E523, K525, and S526 (side) from the
other Ad12 knob; and L39 (side), K47 (backbone), V48 (backbone),
D49, Q50, V51, and K102 (side) from CAR. The underlined residues
are conserved or similar in all CAR-binding Ad serotypes.