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Figure 3.
Figure 3: The active site. a, The nucleotide and relevant
residues of Ran and RanGAP; interactions are indicated by dashed
lines. The catalytic water ('W') has very weak density (probably
owing to the limited resolution) and was not included in the
final model, but is shown here to illustrate its potential
interaction partners. It sits in a similar position as in the
Ras–RasGAP complex. Asterisk denotes the hydroxyl group of Thr
42 of Ran. The rest of the side chain is omitted for clarity. b,
The 2F[o] - F[c] electron density map contoured at 1.6  for
the structure with GDP and aluminium fluoride, the latter
modelled as AlF[3].
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