|
Figure 3.
Figure 3 Active site cleft of DPPI with a bound model of the
N-terminal sequence ERIIGG from the biological substrate,
granzyme A. (A) Stereo view: covalent bonds of papain-like
domains and the exclusion domain are shown in the colors used in
Figure 1C. Covalent bonds of the substrate model are shown as
yellow sticks. Corresponding carbon atoms are shown as balls
using the covalent bond color scheme. The chloride ion is shown
as a large green sphere. Oxygen, nitrogen and sulfur atoms are
shown as red, blue and yellow spheres, respectively. The
residues relevant for substrate binding are marked and hydrogen
bonds are shown as white broken lines. The molecular surface was
generated with GRASP (Nicholls et al., 1991); the figure was
prepared in MAIN (Turk, 1992) and rendered with RENDER (Merritt
and Bacon, 1997). (B) Schematic presentation. The color codes
are the same as in (A).
|
