Figure 3.
Fig. 3. Interaction of DC with PI. a, stereoview of the
bound inhibitor and the three catalytic residues is shown along
with the 2F[o] F[c]
electron density map at 2.0 Å resolution contoured at 1.0
. The
H-bonds and their distances are indicated. b, four possible
ionization states in the interaction of DC with the catalytic
residues. Whereas the first binding mode results in three
charged H-bonds, the rest of the binding modes result in one
charged and two neutral H-bonds.
F[c]
electron density map at 2.0 Å resolution contoured at 1.0
. The
H-bonds and their distances are indicated. b, four possible
ionization states in the interaction of DC with the catalytic
residues. Whereas the first binding mode results in three
charged H-bonds, the rest of the binding modes result in one
charged and two neutral H-bonds.