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Figure 3.
Figure 3. Interactions at the p21–PCNA Interface(a)
Schematic depiction of contacts between the peptide and PCNA.
Residues of the connector loop of PCNA are shaded green, those
of the C-terminus are in yellow, and other PCNA residues are in
pink. A set of two water-mediated contacts is also shown (blue
circles).(b) Hydrophobic interactions at the p21–PCNA
interface. A set of four side chains of the p21-peptide (red)
fit into hydrophobic cavities in the molecular surface of PCNA.
The C^α trace of PCNA is displayed as a green tube. PCNA
residues lining the pockets (shown in yellow) are: Cys-27,
Met-40, Val-45, Leu-47, Ala-67, Gly-69, Leu-121, Val-123,
Leu-126, Ile-128, Pro-129, 133-Tyr, Pro-234, Tyr-250, Ala-252,
Pro-253, and (in green) Gln-131, which contacts the hydroxyl of
the peptide tyrosine. This figure was generated using GRASP.
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