Figure 3 - full size

Figure 3.
Figure 3. Representation of the two equivalent positions of Tyr99. The generally observed position (shown in light gray) enables hydrogen-bonding to Tyr9 and usually to the P3 nitrogen, while the alternative orientation (dark) in HLA-B*3501 allows interaction with the side-chain of aspartate at position 5 of the peptide (P D5).