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Figure 2.
Structural features of the ssoMCM hexamer. (A) Double
hexameric EM map of mtMCM with the ssoMCM hexamer model fitting
snugly inside the map (20). The PS1 hairpin is located near the
side channels of the EM map (indicated by an arrow). (B) Side
and top views of the ssoMCM hexamer model. Subunits are labeled
a–f. Two subunits in the front are removed in the side view to
reveal the interior. The 4 β-hairpins located inside the
central and side channels are colored. (C) Close-up view of
subunits a and b in the back side of the hexamer in B (side
view). β-Hairpins are labeled as in Fig. 1B. The opening
between the 2 neighboring subunits at the C terminus (side
channel) is indicated. (D) Close-up top view as in B, showing
the radial and helical nature of the 4 β-hairpins.
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