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Figure 2.
Overview of the crystal structure of Lyn. A, ribbon
representation of the crystal structure of Lyn PTK. The
N-terminal lobe (residues 239–326) shown in gray comprises a
five-stranded anti-parallel β-sheet and one α-helix (αC). The
C-terminal lobe (residues 327–501) is shown in green. The
glycine loop is colored in orange, the hinge region between the
two lobes in yellow, the catalytic loop in blue, and the
activation loop in red. B, close-up of portions of the αC helix
and activation loop showing active (Lyn (blue), Lck (yellow))
and inactive (Src (magenta), Hck (green)) conformations.
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