Figure 2 - full size

Figure 2.
Figure 2 Protein/DNA contacts in polymerizing and editing conformations. (A) Polymerase mode. Hydrogen bond contacts less than 2.8 Å are represented by solid lines and those greater than 2.8 and less than 3.5 Å are shown with dashed lines. Residues in parentheses represent charge interactions longer than 3.5 Å. Wavy lines represent water-mediated contacts. Hydrophobic interactions are symbolized by dashed arcs. Contacts mediated by a nitrogen main-chain atom are indicated by the suffix 'N'. Protein residues are colored according to their domain location: exonuclease (cyan), N-terminal domain (orange), palm (red), thumb (green) and fingers (blue). Underlined residues are contacts in Pol1 that are absent in Pol2. (B) Exonuclease mode. All descriptions as above.