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Figure 2.
Figure 2. Interaction between the Ad11 knob and CD46 SCR1-SCR2.
(a) Ribbon tracing of the complex, colored as in Figure 1.
(b–d) The three major contact regions (A–C) of Ad11 knob.
Nitrogen and oxygen atoms are blue and red, respectively.
Hydrogen bonds and salt bridges are represented with dashed
lines. (e) Superimposition of SCR2 domains of unliganded^13
(blue) and liganded CD46 (red). The two Ad11 knob protomers
interacting with CD46 are shown in gray. Arrow indicates the
rearrangement of SCR1 upon binding to Ad11 knob. (f) Close-up
view of the interaction. Key residues of CD46 that interact with
Ad11 knob are shown in orange. (g) Structure of unliganded CD46.
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