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Figure 2.
Figure 2. MuSK Ig1-2 dimer. (a) Ribbon diagram of the MuSK
Ig1-2 non-crystallographic dimer. The two protomers are colored
green and purple (Ig1 in light shades and Ig2 in dark shades).
The non-crystallographic 2-fold axis is vertical. (b) Ig1–Ig1
dimer interface. The stereo view is approximately 50° about
the vertical (2-fold) axis from that in (a). Side-chain atoms in
the dimer interface are shown in ball-and-stick representation,
and hydrophobic contacts are shown with semi-transparent van der
Waals surfaces. Carbon atoms, either green or purple; oxygen
atoms, red; and sulfur atoms, yellow. Side-chains that are not
labeled are related by the vertical 2-fold axis to those that
are labeled. (c) Molecular surface representation of Ig1-2
colored according to electrostatic potential: blue, positive (+
15kT); white, neutral; red, negative (− 15kT). Residues
located in the Ig1 dimer interface (left) and in the vicinity of
the surface-exposed disulfide bridge (Cys98/Cys112) (right), on
the opposite side of Ig1, are labeled. The two views are related
by 180° about a vertical axis. (a) and (b) were rendered
with PyMOL [http://pymol.sourceforge.net] and (c) with GRASP.^45
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