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Figure 2.
Figure 2: Binding interfaces and structural flexibility of DDB1
on CUL4A. a, An overall view of the structural elements
mediating the binding of the DDB1 BPB domain (cyan) with the
CUL4A NTD (green). b, The interface between the top surface of
DDB1-BPB (cyan) and the H2–H5 helices of CUL4A (green) viewed
from above with participating side chains shown as sticks (grey
in DDB1 and green in CUL4A). c, Superposition of the H2–H5
helices of CUL4A (green) and CUL1 (grey) with CUL1-bound SKP1
(blue) shown in the background. The view is the same as that
shown in panel b. CUL4A-bound DDB1 is not shown for clarity. d,
The interface between the CUL4A N-terminal extension sequence
(green) and the peripheral side of the DDB1 BPB domain (blue).
e, Superposition analyses of DDB1 alone (right) and DDB1–SV5-V
complex (left) structures in the context of the full
DDB1–CUL4A–ROC1 complex. The models are docked through the
BPB domain and viewed from the same angles as shown in Fig. 1b.
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