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Figure 2.
Figure 2 Nucleotide-binding sites. Stereoview of the ATP-binding
(A) and ATP/Mg^2+-binding(B) sites. Color-coding is identical to
Figure 1. Direct and water-mediated protein–ATP interactions
are highlighted in yellow. Water molecules are shown as blue
spheres and Mg^2+ as a green sphere. The interaction between
D637 of the D-loop of the trans monomer and S504 of the Walker A
motif of the cis monomer is indicated. ATP and amino acids
involved in ligand interactions are shown in ball-and-stick
representation. ^* indicates conserved motifs of the trans
monomer participating in ATP coordination. (C) Stereoview of the
ADP-binding site. ADP and residues involved in ligand
interactions are shown in ball-and-stick representation, water
molecules are blue spheres, protein–ADP interactions are
highlighted in green and ADP–water interactions in blue.
Color-coding is identical to Figure 1. The interaction between
the side chain of Q550 and the amide backbone of T633 is
highlighted by a dashed, brown line.
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