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Figure 2.
Figure 2. FXI activation. (a) Ribbon diagrams representing
zymogen activation by superposition of the FXIa structure
(green; PDB entry 1ZJD) and the zymogen protease domain
(yellow). The region of largest conformation change is the
activation loop comprising residues 376–370. Ile370 side chain
is colored purple in both structures. Active site Ser557 side
chain is also shown. (b) Space-filling representation of the FXI
dimer. White side chains, Arg369 and Ile370 from the activation
loop; blue side chain, Lys252 and Lys253; red side chain, Glu66.
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