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Figure 2.
Figure 2. Structure of the BAR-PH Domain Dimer of Human APPL1
(A) Schematic representation of the BAR-PH domain dimer.
One monomer is shown in yellow and the other in cyan.
(B)
The dimer after 90° rotation around the horizontal axis,
showing the banana shape of the structure. The red star
indicates the location of the β1-β2 loop in the PH domain,
which is near the putative phospholipid binding site.
(C)
Superposition of the APPL1 BAR domain dimer (in yellow and cyan)
and that of endophilin (in gray). The red arrow highlights the
structural differences between the two dimers. Produced with
PyMOL (DeLano, 2002).
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