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Figure 2.
Fig. 2. Conserved interactions between the FMDV 3D and the
different RNA template–primers. The polymerase regions
involved in contacts with the RNA molecule are explicitly
labeled. The template and primer strands of the RNA molecule are
shown in yellow and green, respectively; atoms are displayed in
atom-type code, and hydrogen bonds are dashed lines in black.
The template strand contacts mainly with residues in the fingers
subdomain (blue). The 5' overhang region of the template binds
the template channel, where the different residues of the
N-terminal region and the loop  4–  3 of the
polymerase drive the ssRNA to the active-site cavity (Lower
Left). The template strand of the dsRNA product contacts
different residues of helix 7 and the loop 9– 11 in
its exit through the central cavity of the enzyme (Upper Left).
The primer strand interacts with motifs C and E of the palm
subdomain, shown in magenta (Upper Right) and with helix 14 of
the thumb, shown in red (Lower Right).
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