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Figure 2.
Figure 2. Surface representation of the SplC molecule. The
catalytic triad (yellow) is blocked by Gly175–Gly176 and the
whole Tyr174–Tyr184 loop region interferes with enzymatic
activity. The specificity region built by Val119, Phe149, Ile153
and Val173 enables binding of a medium-sized hydrophobic residue.
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