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Figure 2.
Figure 2: Details of the Ran–RanGAP interface. a, Worm plot
of Ran and RanGAP, with colours as in Fig. 1 and important
residues shown in ball and stick representation. The uncomplexed
RanGAP (cyan) is superimposed; arrows indicate the movement of
Lys 76 and Arg 74, and asterisk symbolizes the potential clash
of Leu 43 and Lys 76 on complex formation. b, Switch II of Ran
(green) superimposed on the Ran–ranBD1 structure (blue),
illustrating the reorientation of Gln 69 into a catalytically
competent conformation by the residues Tyr 39 from Ran and Asn
131 fron RanGAP.
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