Figure 2.
Figure 2. Overall structure of IRF-3 and its structural
similarity to Smad2. (a) A stereo view of the C trace
of the IRF-3 175C homodimer in the asymmetric unit. Subunits A
and B are blue and red, respectively. Dotted circles represent
the LHR-pocket. This figure was prepared with MolScript33. (b,c)
Ribbon diagram representations of the IRF-3 175C monomer. SRR is
cyan, and a disordered loop is indicated by a dotted line. b and
c are related by a 90° rotation along the horizontal axis. (d)
Comparison of the structures of IRF-3 175C (left) and Smad2
(right). The structurally similar region between IRF-3 175C and
Smad2 is in cyan and others are in yellow. All figures except
Figures 2a, 3b and 4 were prepared with MolScript and
Raster3D^34.
trace
of the IRF-3 175C homodimer in the asymmetric unit. Subunits A
and B are blue and red, respectively. Dotted circles represent
the LHR-pocket. This figure was prepared with MolScript33. (b,c)
Ribbon diagram representations of the IRF-3 175C monomer. SRR is
cyan, and a disordered loop is indicated by a dotted line. b and
c are related by a 90° rotation along the horizontal axis. (d)
Comparison of the structures of IRF-3 175C (left) and Smad2
(right). The structurally similar region between IRF-3 175C and
Smad2 is in cyan and others are in yellow. All figures except
Figures 2a, 3b and 4 were prepared with MolScript and
Raster3D^34.