Figure 2.
Figure 2 Overall view of IRK3P and comparison with IRK. (A)
Ribbon diagram of the IRK3P structure. The -helices
are shown in red, the -strands
in blue, the nucleotide-binding loop in yellow, the catalytic
loop in orange, the activation loop in green, AMP-PNP in black
and the peptide substrate in pink. The termini are denoted by N
and C. (B) Superposition of the C-terminal lobes of IRK and
IRK3P. The backbone representation of IRK/IRK3P is colored
orange/green, with the activation loop colored red/blue. The
axis (black) and arrow (blue) specify the rotation required to
align the N-terminal -sheet
of IRK with that of IRK3P. (C) Superposition of the -sheets
in the N-terminal lobes of IRK and IRK3P. The backbone
representation and carbon atoms of IRK/IRK3P are colored
orange/green, oxygen atoms are red and nitrogen atoms are blue.
(A) and (C) prepared with RIBBONS (Carson, 1991), (B) with GRASP
(Nicholls et al., 1991).
-helices
are shown in red, the 
-strands
in blue, the nucleotide-binding loop in yellow, the catalytic
loop in orange, the activation loop in green, AMP-PNP in black
and the peptide substrate in pink. The termini are denoted by N
and C. (B) Superposition of the C-terminal lobes of IRK and
IRK3P. The backbone representation of IRK/IRK3P is colored
orange/green, with the activation loop colored red/blue. The
axis (black) and arrow (blue) specify the rotation required to
align the N-terminal